Development of a cytotoxic T-lymphocyte-based, broadly protective influenza vaccine
نویسندگان
چکیده
منابع مشابه
Toward a broadly protective influenza vaccine.
The current inactivated influenza virus vaccines induce antibodies that protect against closely related virus strains. They do not, however, protect against antibody-escape variants of seasonal influenza A viruses or new pandemic influenza A viruses emerging from non-human reservoirs. Might boosting influenza A virus-specific CD8+ T cell memory diminish the danger posed by these variant viruses...
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There is considerable interest in the development of broadly protective influenza vaccines because of the continuous emergence of antigenic drift variants of seasonal influenza viruses and the threat posed by the emergence of antigenically distinct pandemic influenza viruses. It has been recognized more than three decades ago that influenza A virus-specific cytotoxic T lymphocytes recognize epi...
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We report the rational design and in vivo testing of mosaic proteins for a polyvalent pan-filoviral vaccine using a computational strategy designed for the Human Immunodeficiency Virus type 1 (HIV-1) but also appropriate for Hepatitis C virus (HCV) and potentially other diverse viruses. Mosaics are sets of artificial recombinant proteins that are based on natural proteins. The recombinants are ...
متن کاملHuman cytotoxic T-lymphocyte repertoire to influenza A viruses.
The murine CD8(+) cytotoxic-T-lymphocyte (CTL) repertoire appears to be quite limited in response to influenza A viruses. The CTL responses to influenza A virus in humans were examined to determine if the CTL repertoire is also very limited. Bulk cultures revealed that a number of virus proteins were recognized in CTL assays. CTL lines were isolated from three donors for detailed study and foun...
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Department of Virology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. (Received 14 October 1994; accepted 19 October 1994) the protection from subsequent inthtenza virus infections is controversial. Despite the existence of conserved CTL epitopes present in e.g. the nucleoprotein (NP)‘“*l‘ of influenza virus strains that infect humans in subsequent seasons, th...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 2010
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.2010.00273.x